RedDress’s ActiGraft® technology is revolutionizing the way we treat chronic wounds by managing each stage of the wound healing process. ActiGraft uses a patient’s own blood to create a whole blood clot tissue. This blood clot tissue is then applied to the wound, where it supports the natural healing processes of the body.

Hemostasis: The body works to stop the bleeding and start the healing process by activating a coagulation cascade. A fibrin blood clot forms that plugs severed blood vessels and fills in tissue discontinuity at the wound site.

Inflammation: During this phase, white blood cells and macrophages enter the wound
to destroy bacteria and remove debris. The blood clot creates a fibrin scaffold that serves as a protective, provisional extracellular matrix (ECM) containing cytokines and growth factors that facilitate tissue repair

Proliferation: The blood clot recruits endothelial cells and fibroblasts to synthesize a permanent ECM. The focus is filling and covering the wound.

Remodeling: The blood clot dries out and becomes a protective scab. Under the
scab, tissue remodeling takes place undisturbed. The fibrin is replaced by fibronectin and hyaluronan, and the scab falls off to reveal a collagenous scar